Comparison of adrenocorticotropic hormone efficacy between aetiologies of infantile spasms

PurposeWe aimed to study the efficacy of adrenocorticotropic hormone (ACTH) treatment on infantile spasms with different aetiologies. In particular, we were interested in patients structural-acquired aetiology.MethodsPatients spasms, who treated ACTH, divided into three groups based aetiologies: unknown aetiology normal development (unknown-normal), structural-acquired, and combined-congenital aetiologies that included genetic, metabolic, structural-congenital, or developmental delay.ResultsOf 107 (58 males, 49 females), 25 had unknown-normal [median age at onset 5 months, standard deviation (SD) 3.12, range 2–16 months]; 20 (median 6.5 SD 3.85 4–17 months); 62 2.73 months).The ACTH was 64.0 %, 65 30.6 % aetiology, aetiologies, respectively (p < 0.01). Multivariate analysis showed a statistically significant higher [Odds ratio (OR) 4.63, 95 confidence interval (CI) 1.60?13.30] (OR 3.41, CI 1.01?11.50) compared aetiologies.ConclusionInfantile greater response than those The therapy should be considered aetiology.